Portuguese Version

Year:  2005  Vol. 71   Ed. 6 - (10º)

Artigo Original

Pages: 752 to 757

PDF PT   PDF EN

Radiation therapy for glomus tumors of the temporal bone

Author(s): Celso Dall´Igna1, Marcelo B. Antunes2, Daniela Pernigotti Dall´Igna3

Keywords: radiotherapy, ear, hearing loss, paraganglioma, quemodectoma.

Abstract:
The treatment of glomic tumors has been controversial since its first description. It can be done with surgery, radiotherapy or just expectation. Aim: The objective of this paper was to evaluate the effectiveness and complications of radiotherapy. Study design: clinical with transversal cohort. Material and Method: It was made a retrospective review in the charts of the patients with glomus jugulare tumors treated with radiotherapy. Disease control was determined by (1) no progression of symptoms or cranial nerve dysfunction or (2) no progression of the lesion in radiological follow-up. It was also evaluated the follow-up period and the sequelae of the treatment. Results: Twelve patients were included, 8 of then women. The follow-up period was from 3 to 35 years, with a media of 11,6 years. The main symptoms were: hearing loss, pulsate tinnitus, dizziness and vertigo. The signs were pulsate retrotympanic mass, facial palsy and cofosis. The tumors were staged using Fisch's classification. The radiotherapy was performed with linear accelerator with dose ranging from 4500-5500 in 4-6 weeks. In the follow-up period were possible to identify sequelaes like dermatitis, meatal stenosis, cofosis and facial palsy. Discussion: The signs and symptoms were the same found in the medical literature. The type and dosages of the radiotherapy were also the same of others reports. All patients had improvement of the symptoms and only one was not considered as having disease controlled. Complications were, in general, minor complications, with exception of the cofosis and facial palsy. Conclusion: Radiotherapy is a viable alternative to treatment of these tumors because their good response and low level of complications. It should be considered specially in advanced tumors where a surgical procedure could bring a high level of morbidity.

INTRODUCTION

Glomus tumors also known as paragangliomas or chemodectomas are the most common neurological neoplasm after acoustic neuroma. These tumors are originated from glomus bodies or paraganglia, which are structures from the neuroendocrine extra-adrenal system usually related to sympathetic ganglia.

The treatment of these tumors has been subject of controversy since the first study published in the 40's by Guild1 & Rosenwasser2, and may be divided into curative and palliative. The only curative treatment available is surgery, and the palliative treatment may include radiotherapy or wait and watch protocol. Generally these tumors are addressed on individual basis according to the age of the patient, the size, type and staging of the tumor.

The objective of this study was to evaluate radiation effectiveness and radiotherapy complications for glomus tumor of the temporal bone.

MATERIAL AND METHOD

This study included 12 patients with glomus jugulare tumor of the temporal bone treated with radiotherapy between 1960 and 2001 that have been periodically followed up at the Otorhinolaryngology Service of Hospital das Clínicas de Porto Alegre. The last appointment occurred between January 2004 and February 2005. The patients with glomus tympanic tumor and those that have exclusively undergone surgery were excluded from the study.

Patients referred to radiotherapy were those that refuse to undergo surgical treatment, those with lesions considered non-resectable or those that did not have clinical conditions to undergo general anesthesia. Control criteria of the diseased through radiotherapy were (1) absence of progression of symptoms or cranial nerve dysfunction, and (2) the lesion did not increase according to physical examination or radiological control.

The analysis of the charts of the patients included information related to personal data (age and gender), clinical history, physical examination and audiometry tests on diagnosis, initial staging, proposed and conducted treatment, and follow-up of the patients. Radiological findings were recovered through expert's opinion made by the radiologist. The staging of the tumor was classified according to Fisch3 (Table 1). Radiation therapy concerning the type, dose and treatment interval was analyzed based on final opinion of the radiotherapist after the end of the treatment. The follow up of the patients was conducted on a consistent basis: monthly reviews during the first 6 months, then quarterly reviews up to complete 2 years, six months review until 5 years of treatment, and annual reviews after it. At every appointment patients answered questions about symptoms (hypoacusia, pulsatile tinnitus, dizziness/vertigo, otorrhea, otalgia, post-radiotherapy symptoms and others) it included a detailed and careful description of the otoscopy findings. All patients have undergone CT (Computerized Tomography) annually to evaluate any likely progression of the tumor.

RESULTS

This study carried out in 12 patients included 8 women (mean age at diagnosis was 50) aged from31-87 years. The follow up interval ranged from 3 to 35 years (mean of 11.6 years). Major symptoms and findings in physical examination at diagnosis are included in Table 2. The audiometric findings were anacusia in two thirds of the patients, mixed loss in 2 patients and conductive loss in 1 patient. The audiometry of one patient at diagnosis was not recovered, and the oldest one available was that performed after radiotherapy showing mixed hearing loss in the ear affected by the disease. The patient mentioned there was no significant change in hearing after treatment.

Data related to each patient are summarized in Table 3.

Radiological findings were extremely variable due to multidirectional growth of these tumors. The analyses of such exams provide us with the opportunity to evaluate tumor extension and perform an accurate staging of such lesions. Tumor staging was performed according to Fisch's classification in Table 4.

The type radiation therapy used was megavolt radiation with linear accelerator and dose ranging from 4,500 to 5,500 Rads during 4 to 6 weeks. Only one patient (CMS) received therapy with telecobalt for 8 weeks and dose of 5,200 Rads.

The last appointment follow-up dates were between January 2004 and February 2005 when data collection was finished. Most of the patients mentioned symptoms only if they were asked about any specific complaints during protocol application. The hearing loss remained stable before and after radiation therapy in those patients with mixed loss (2 patients); however deafness after radiation therapy occurred in one case of a patient with conductive loss. In general, tinnitus was described and did not cause any discomfort for patients, it remained pulsatile in 6 patients even after radiotherapy. Physical examination showed the presence of retrotympanic tumor in most of the patients, and in 41.6% of them the mass was pulsatile.

Radiological controls did not show any progression of the disease in all patients, except for one (CMS). This patient had undergone CT scan in Dec/2004 showing mild increase in the lesion with density of soft parts that occupied the tympanic cavity and part of the External Auditory Canal. Since the patient did not have any new complaints and does not want to undergo rescue surgery, he/she is under clinical follow-up. During the follow-up period of patients it was possible to find out that all patients presented, at different and variable levels, one or more effects resulting from radiotherapy. The most common one was dermatitis with severe desquamation and fragility of the External Auditory Canal skin that occurred in half of the patients. The stenosis of the External Auditory canal was reported in 25% of the patients during follow-up. Other complications such as otalgia, vertigo, cofosis and facial palsy occurred only once. One patient eventually presented a basal cell carcinoma in the face and neck approximately 30 years after radiotherapy on the same irradiated side.

DISCUSSION

Surgery is advocated by many as the ideal treatment4,8. It is justified due to technical developments of skill base surgery, tumor resectability has enabled good functional results, decreased effects and good quality of life postoperatively. Recurrence indexes varied from 5.5 to 54%.4, 17, 18 Surgery morbidity is high and fairly variable, leading to primarily cranial nerve dysfunction and liquor fistula. In one study of Jackson et al. 4, lesion index of cranial nerves just after the surgery reached 59% of patients. It was reported that total removal of the tumor without affecting cranial nerves was referred as possible in only 31% of the cases. Cace et al. 19 had lesion at least of some cranial nerve in all patients. Hawthorne et al 20 reported 47% of cranial nerve dysfunction preoperatively and 95% dysfunction postoperatively. Liquor fistula was found in 12 to 64% of the patients4,19,20. Gardner et al. 8 reported 50% of dysphagia, 19% of facial palsy postoperatively and 19% of liquor fistula. Perioperative mortality varied from 2.7 to 3%4,21. Surgery resulted in cure of the disease in 54 to 85% of the cases4,9,16, however, long-term effectiveness still needs to be determined.

Others view radiotherapy as the initial treatment5,9,11 due to the morbidity of surgical procedure. The objective is to have local/regional control of the disease in the long term, without any subjective our objective progression of the disease. Typically disease control is defined as in the current study: absence of progression of symptoms or cranial nerve dysfunction without any lesion increase upon physical examination or radiological control. Tumors may present a decrease in size, but rarely disappear as observed in pathophysiological analysis of follow-up and radiological tests. A study from Spector et al.6 showed that chief cells are not radiosensitive, remaining viable after radiotherapy. These cells, however, no longer presented mitotic activity. The stroma showed itself as more reactive to radiotherapy and was replaced by fibrous tissue rich in fibroblasts, similarly to vascularization in which one may observe changes such as perivascular fibrosis, endothelial hyperplasia and subendothelial degeneration.

In the presented series it was possible to find 2:1 ratio favorable to women, which is somewhat different from the literature that sets a ratio of 4 to 7:14, 9.The age range of onset of tumors was 43 to 87 years (mean 62.4 years) a little higher then reported in literature, with higher incidence of tumors occurring between 5th and 6th decades. Mean follow up considered as appropriate was more than 11 years to determine a definitive response to the treatment, although it is known that glomus tumors have slow growth rate and some reports mention a recurrence of tumors even after twenty years9.

Symptoms and findings of physical and additional examinations were not different from those reported in the literature14,15, with a long interval between the onset of symptoms and diagnosis14. None of the patients obtained improvement in symptoms such as hearing loss, tinnitus or cranial nerve dysfunction after radiotherapy, as found in other series13,22.

The type of radiotherapy applied was linear accelerators. The dose and term of the radiotherapy were also not different from those used in routine medical practice7,9,12,13. Some studies used irradiation with cobalt, whereas others used linear accelerator. Both radiotherapy types are considered as megavoltage radiotherapy, and a difference in results was not expected between one and the other.

Most of the studies about radiotherapy for glomus tumors did not explicitly refer complications, only the term "few complications" was mentioned. In the investigated series it was possible to observe that all patients had some degree of complications. Actinic dermatitis after radiotherapy may really be considered a minor event, and may be controlled with skin medicines and frequent cleaning of the External Auditory Canal. On the other hand, the presence of stenosis in soft tissue of the External Auditory Canal cannot be neglected since it may hinder proper postoperative examination, and affect hearing as well (although most of the patients had anacusia in the affected ear).

Cofosis and facial palsy after radiotherapy are considered major complications of radiotherapy. The patient with hearing loss symptom after treatment (CMS) was irradiated with telecobalt (5,200 Rads) for 26 days; this dose is not considered high if compared against data from the literature. The same patient was the only one considered as therapeutic failure since there was increase in the tumor in the follow-up tomography.

In other series, many patients were treated with cobalt at similar doses and reported good results without any significant complications. Therefore, the treatment should not be held responsible for complications or treatment failure. The patient developed facial palsy and had a tumor with extensive bone destruction and intracranial involvement, and palsy could have resulted from the invasion of the nerve since only tumor abnormalities could be found after radiotherapy. In the patient that had basal cell carcinoma it was not possible to determine if it was a consequence of radiotherapy applications or if it would develop anyway since the patient is a rural worker and had long history of sunlight exposure.

The control of the disease in our series was considered satisfactory and successful in 91.6% of the cases. Other authors also demonstrated long-term control of glomus jugulare tumor with radiotherapy. They report success rates ranging from 84 to 98% with the recommended dose. Hatfield et al 23 had 100% control in 16 patients with doses ranging from 4,000 or above cGY and also reported that each 1 out of 2 respected cases that had cure as the objective, relapsed. Kim12 demonstrated that radiotherapy alone had an 88% rate of disease control, whereas post-resection subtotal radiotherapy had 85% of disease control. Larner presented a study carried out in 49 patients. Twenty had undergone surgery, 14 had undergone surgery and postoperative radiotherapy, and 15 were treated only with radiotherapy, and the other surgeries associated or not with post-operative radiotherapy. Disease control with radiotherapy was 93%. Radiotherapy has not received the recognition it deserves because new techniques that use megavoltage are not widely disseminated in clinical practice yet. In the past, orthovoltage was highly related with frequent complications and lack of predictable response in disease control. Another key aspect was the fact that "chief cells" are radio resistant, and it brings some level of concern, but at the same time one should bear in mind that the vascular portion of the tumor presents fibrosis only after irradiation. The lack of a consistent definition about the success in treating glomus jugulare tumors in the literature affects the comparisons between different treatment regimes.

CONCLUSION

As to radiation treatment for glomus jugulare tumors, since it presents a good response in disease control with low morbidity, it is a therapeutic option that should be taken into account if the patient is not qualified or does not want to undergo surgery. It should also be considered in more advanced stage tumors in which resection would likely to be incomplete or would result in irreversible consequences for the patient.

The exposure of all treatment vantages and disadvantages and likely complications of several treatment methods of pathology is in our opinion the correct approach to allow us to provide better quality medical practice.

REFERENCES

1. Guild SR. A hitherto unrecognized structure, the glomus jugularis in men. Anat Rec (Suppl 2) 1941; 79:28.

2. Roserwasser H. Carotid body tumor of the middle ear and mastoid. Arch Otol 1945, 41:64-7.

3. Fisch U. Infratemporal fossa approach for glomus tumors of the temporal bone. Ann Otol Rhinol Laryngol 1982; 92:474-9.

4. Jackson CG. Glomus tympanicum and glomus jugulare tumors. Otolaryngol Clin North Am 2001; 34(5):941-70.

5. Cole JM, Beiler D. Long-term results of treatment of glomus jugulare and glomus vagale tumors with radiotherapy. Laryngoscope 1994; 104:1461-5.

6. Spector GJ, Maisel RH, Ogura JH. Glomus jugulars tumors: a clinicopathologic analysis of the effects of radiotherapy. Ann Otol 1974; 83:26-32.

7. Simko TG, Griffin TW, Gerdes AJ, et al. The role of radiation therapy in the treatment of glomus jugulare tumors. Cancer 1978; 42:104-6.

8. Gardner G, Cocke EW, Robertson JH, et al. Skull base surgery for glomus jugulare tumors. Am J Otol 2001; 6(Suppl):126-34.

9. Larner JM, Hahn SS, Spaulding CA, et al. Glomus jugulare tumors: long-term control by radiation therapy. Cancer 1992; 69:1813-7.

10. McCabe B, Fletcher M. Selection of therapy of glomus jugulare tumors. Arch Otolaryngol 1969; 89:182-5.

11. Moore GR, Robbins JP, Seale DL, et al. Chemodectomas of the middle ear: a comparison of therapeutic modalities. Arch Otolaryngol 1973; 98:330-5.

12. Kim JA, Elkon D, Lim ML, et al. Optimum dose of radiotherapy for chemodectomas of the middle ear. Int J Radiat Oncol Biol Phys 1980; 6:815-9.

13. Cummings BJ, Beale FA, Garret PG, et al. The treatment of glomus tumors in the temporal bone by megavoltage radiation. Cancer 1984; 53: 2635-40.

14. Boyle JO, Shimm DS, Coulthard SW. Radiation therapy for paragangliomas of the temporal bone. Laryngoscope 1990; 100:896-901.

15. Jackson CG. Section III - Diagnosis for treatment planning and treatment options. Laryngoscope 1993; 103(Suppl):17-22.

16. Bramer RE, Graham MD, Kemink JL. Glomus tumors of the temporal bone: contemporary evaluation and therapy. Otolaryngol Clin North Am 1984; 17:499-512.

17. Spector GJ, Compagno J, Perez CA. Glomus jugulare tumors. Effects of radiotherapy. Cancer 1975; 35:1316-21.

18. Wang ML, Hussey DH, Doorbons JF, et al. Chemodectoma of the temporal bone: a comparison of surgical and radiotherapy results. Int J Radiat Oncol Biol Phys 1986; 14:643-8.

19. Cace JA, Lawson W, Eden AR. Complications in the management of large glomus jugulare tumors. Laryngoscope 1987; 97:152-7.

20. Hawthorne MR, Makek MS, Harris JP, et al. The histopathological and clinical features of irradiated and non-irradiated temporal paragangliomas. Laryngoscope 1988; 98:325-31.

21. Glasscock ME, Jackson CG, Dickins JRE, et al. Panel discussion - glomus jugulare tumors of the temporal bone: the surgical management of glomus tumors. Laryngoscope 1979; 89:1640-54.

22. Dawes PJDK, Filippou M, Welch AR, et al. The management of glomus jugulare tumors. Clin Otolaryngol 1987; 12:15-24.

23. Hatfield PM, James AF, Schulz MD. Chemodectomas of the glomus jugulare. Cancer 1972; 30:1164-8.

1 Joint Professor of Otorhinolaryngology, UFRGS - Ph.D. In Medical Sciences, Head of the ENT Services at Clinical Hospital in Porto Alegre
2 Otorhinolaryngology- Physician, Fellow of Fisch Foundation.
3 Internist, Otorhinolaryngologist, Federal University of Paraná.
Service of Otorhinolaryngology and Head and Neck Surgery -Hospital das Clínicas de Porto Alegre- Medical School, Federal Universidade of Rio Grande do Sul.
Address correspondence to: Hospital de Clinicas de Porto Alegre - Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço - Zona 19 Rua Ramiro Barcelos 2350 Largo Eduardo Z. Faraco Porto Alegre RS Brasil 90035-903.
The present article was submitted through SGP on June 23, 2005 and approved on September 12, 2005.

Print: