Year: 2000 Vol. 66 Ed. 1 - (4º)
Artigos Originais
Pages: 24 to 29
Hair Cell Regeneration in the Avian cochlea After Ototoxicity with Aminoglycoside.
Author(s):
José Antonio A. de Oliveira*;
Ricardo C. Demarco*;
Maria Rossato***.
Keywords: hair cell; regeneration; ototoxicity; gentamicin; chick
Abstract:
Introduction: Hair cells may be damaged by a number of agents including aminoglycosides. In the avian cochlea, lost of hair cells can be replaced by regeneration. Aim: The objectives of the research were to study the process of regeneration that occurs in the avian cochlea and the temporal sequence of damage by gentanicin. Material and methods: In this study, two groups of three-day old chicks were given gentamicin at a single dose of 125 and 250 mg/kg each. Their cochlea were processed for, scanning electron microscopy at 1, 3, 5 and 20 days following the injection. The sequence of degeneration and regeneration were studied. By the 20 days post-treatment, however, most of the damaged region had been replaced with regenerating hair cells and supporting cells. Stereocilium and microvilli were observed on the apical surfaces of the regenerating sensorial epitelium.
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