Keywords: mucosal melanoma, tumor of nose and paranasal sinus

Abstract: Mucosal melanoma of nose and paranasal cavities is a rare and usually lethal disease. Is a cancerous condition of the melanocyte. The etiology is unknown. It may at times be difficult for the pathologist to arrive at the diagnoses. The imunohistochemical demonstration of specifics proteins is sometimes a useful diagnostic indicator. Radical surgery is the preferred treatment of these tumors. Two cases of primary mucosal melanoma of nose and paranasal sinuses are presented. One nasal submitted a surgical treatment and the maxilar sinus, by a radiotherapy, the authors discuss their clinical courses, diagnostic evalution and therapeutics.